
Expiration | Code | ||
|---|---|---|---|
mecasermin rinfabate, Iplex, Insmed Incorporated | |||
| 2112-12-12 | Orphan excl. | ||

Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acromegaly | D000172 | — | — | — | 4 | 9 | 6 | 11 | 30 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | 3 | 6 | 3 | 4 | 5 | 19 |
| Pituitary dwarfism | D004393 | EFO_1001109 | E23.0 | 3 | 4 | — | 4 | 6 | 16 |
| Dwarfism | D004392 | — | E34.31 | 1 | 5 | 3 | 2 | 3 | 11 |
| Failure to thrive | D005183 | — | — | 1 | 2 | 4 | 1 | 2 | 8 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | — | 1 | 4 | 6 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 2 | — | 1 | 3 | 6 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 2 | 2 | 4 |
| Leukemia | D007938 | — | C95 | — | — | — | 1 | 1 | 2 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | 1 | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 2 | 1 | — | 8 | 11 |
| Anorexia | D000855 | — | R63.0 | 2 | 3 | 3 | — | 2 | 7 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | 2 | 3 | 3 | — | 2 | 7 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | 1 | 2 | 1 | — | 3 | 7 |
| Growth disorders | D006130 | — | — | — | 2 | 3 | — | 2 | 6 |
| Syndrome | D013577 | — | — | 1 | 1 | 2 | — | 2 | 5 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 2 | 1 | — | 2 | 5 |
| Pituitary diseases | D010900 | — | E23.7 | — | 1 | 2 | — | 1 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 1 | — | 2 | 4 |
| Fibrosis | D005355 | — | — | 1 | 2 | 2 | — | 1 | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 5 | 4 | — | — | 6 | 14 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 2 | 2 | — | — | 3 | 6 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | 1 | — | — | 3 | 4 |
| Sarcoma | D012509 | — | — | — | 2 | — | — | 2 | 4 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 2 | — | — | 2 | 4 |
| Rare diseases | D035583 | — | — | — | 1 | — | — | 3 | 4 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | 1 | 3 |
| Rectal neoplasms | D012004 | — | — | — | 3 | — | — | — | 3 |
| Healthy volunteers/patients | — | — | — | — | 1 | — | — | 2 | 3 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | 3 | — | — | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 2 | — | — | — | 1 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 1 | 2 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Brain stem neoplasms | D020295 | EFO_1001767 | — | 1 | — | — | — | — | 1 |
| Pinealoma | D010871 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Joint instability | D007593 | — | — | 1 | — | — | — | — | 1 |
| Tendinopathy | D052256 | EFO_1001434 | M77.9 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 2 | 2 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 2 | 2 |
| Metabolic bone diseases | D001851 | — | — | — | — | — | — | 2 | 2 |
| Overweight | D050177 | — | E66.3 | — | — | — | — | 2 | 2 |
| Igg deficiency | D017099 | — | D80.3 | — | — | — | — | 2 | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 2 | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 2 | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 1 | 1 |
| Drug common name | Mecasermin rinfabate |
| INN | mecasermin rinfabate |
| Description | Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor 1 (IGF-1) and recombinant human insulin-like growth factor binding protein-3 (IGFBP-3) which is used for the treatment of amyotrophic lateral sclerosis (Lou Gehrig's disease).
|
| Classification | Protein |
| Drug class | growth factors: insulin-like growth factors |
| Image (chem structure or protein) | ![]() |
| Structure (InChI/SMILES or Protein Sequence) | — |
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201717 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | NZ8M50KKRG (ChemIDplus, GSRS) |



