Expiration | Code | ||
---|---|---|---|
mecasermin rinfabate, Iplex, Insmed Incorporated | |||
2112-12-12 | Orphan excl. |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acromegaly | D000172 | — | — | — | 3 | 7 | 6 | 10 | 26 |
Laron syndrome | D046150 | Orphanet_633 | E34.321 | 1 | 6 | 4 | 4 | 4 | 17 |
Heart failure | D006333 | HP_0001635 | I50 | 1 | 2 | — | 1 | 2 | 5 |
Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 2 | 2 | 4 |
Brain injuries | D001930 | — | S06.9 | — | — | — | 1 | 1 | 2 |
Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | — | 1 | 1 | 2 |
Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | 1 | — | 2 |
Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | — | 1 | — | 2 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | — | — | — | 1 | — | 1 |
Ataxia telangiectasia | D001260 | Orphanet_100 | G11.3 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 1 | — | 6 | 7 |
Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | 2 | 3 | 3 | — | 1 | 6 |
Growth disorders | D006130 | — | — | — | 2 | 3 | — | 1 | 5 |
Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 2 | 1 | — | 2 | 5 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 1 | — | 2 | 4 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | 1 | — | — | 3 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | — | 2 | 3 |
Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | 2 | — | 1 | 3 |
Fetal growth retardation | D005317 | EFO_0000495 | — | — | — | 1 | — | 2 | 3 |
Crohn disease | D003424 | EFO_0000384 | K50 | — | 2 | 2 | — | 1 | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 5 | 2 | — | — | 1 | 7 |
Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | 1 | — | — | 3 | 4 |
Rectal neoplasms | D012004 | — | — | — | 3 | — | — | — | 3 |
Healthy volunteers/patients | — | — | — | — | 1 | — | — | 2 | 3 |
Sarcoma | D012509 | — | — | — | 2 | — | — | 1 | 3 |
Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | 3 | — | — | — | 3 |
Insulin resistance | D007333 | HP_0000855 | E88.819 | 1 | 2 | — | — | 1 | 3 |
Hyperinsulinism | D006946 | HP_0000842 | E16.1 | — | 1 | — | — | 2 | 3 |
Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | — | — | — | 2 |
Colonic neoplasms | D003110 | — | C18 | — | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis | D003550 | EFO_0000390 | E84 | 2 | — | — | — | 1 | 3 |
Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | 1 | 2 |
Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 1 | 2 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Brain stem neoplasms | D020295 | EFO_1001767 | — | 1 | — | — | — | — | 1 |
Pinealoma | D010871 | — | — | 1 | — | — | — | — | 1 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
Joint instability | D007593 | — | — | 1 | — | — | — | — | 1 |
Tendinopathy | D052256 | EFO_1001434 | M77.9 | 1 | — | — | — | — | 1 |
Hiv-associated lipodystrophy syndrome | D039682 | EFO_1001348 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 3 | 3 |
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
Metabolic bone diseases | D001851 | HP_0000938 | — | — | — | — | — | 2 | 2 |
Pituitary dwarfism | D004393 | EFO_1001109 | E23.0 | — | — | — | — | 2 | 2 |
Igg deficiency | D017099 | HP_0004315 | D80.3 | — | — | — | — | 2 | 2 |
Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 2 | 2 |
Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 1 | 1 |
Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
Anemia | D000740 | HP_0001903 | D64.9 | — | — | — | — | 1 | 1 |
Vascular dementia | D015140 | — | F01 | — | — | — | — | 1 | 1 |
Drug common name | Mecasermin rinfabate |
INN | mecasermin rinfabate |
Description | Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor 1 (IGF-1) and recombinant human insulin-like growth factor binding protein-3 (IGFBP-3) which is used for the treatment of amyotrophic lateral sclerosis (Lou Gehrig's disease).
|
Classification | Protein |
Drug class | growth factors: insulin-like growth factors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | — |
PDB | — |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL1201717 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | — |
UNII ID | NZ8M50KKRG (ChemIDplus, GSRS) |