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Drug ReportsMecasermin rinfabate
Mecasermin rinfabate
Increlex, Iplex (mecasermin rinfabate) is a protein pharmaceutical. Mecasermin rinfabate was first approved as Iplex on 2005-12-12. It has been approved in Europe to treat laron syndrome.
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Target
Variants
Financial
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Events Timeline
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YTD
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
hereditary congenital and neonatal diseases and abnormalitiesD009358
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Mecasermin rinfabate
Tradename
Proper name
Company
Number
Date
Products
Iplexmecasermin rinfabateInsmedN-21884 DISCN2005-12-12
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
mecasermin rinfabate, Iplex, Insmed Incorporated
2112-12-12Orphan excl.
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
H01: Pituitary and hypothalamic hormones and analogues
H01A: Anterior pituitary lobe hormones and analogues
H01AC: Somatropin and somatropin agonists
H01AC05: Mecasermin rinfabate
HCPCS
No data
Clinical
Clinical Trials
248 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AcromegalyD00017211114
DwarfismD004392E34.312214
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Growth disordersD006130133
Failure to thriveD00518322
Chronic renal insufficiencyD051436N1811
Renal insufficiencyD051437N1911
Pituitary diseasesD010900E23.711
Turner syndromeD014424Orphanet_881Q9611
Gonadal dysgenesisD00605911
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Duchenne muscular dystrophyD020388EFO_0000429111
Muscular dystrophiesD009136EFO_0000757G71.0111
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sleep apnea syndromesD012891EFO_0003877G47.311
ApneaD001049R06.8111
SyndromeD01357711
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMecasermin rinfabate
INNmecasermin rinfabate
Description
Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor 1 (IGF-1) and recombinant human insulin-like growth factor binding protein-3 (IGFBP-3) which is used for the treatment of amyotrophic lateral sclerosis (Lou Gehrig's disease).
Classification
Protein
Drug classgrowth factors: insulin-like growth factors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID
RxCUI
ChEMBL IDCHEMBL1201717
ChEBI ID
PubChem CID
DrugBank
UNII IDNZ8M50KKRG (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Increlex Eton Pharmaceuticals
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,002 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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804 adverse events reported
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